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Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity
Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically uni...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159879/ https://www.ncbi.nlm.nih.gov/pubmed/32101166 http://dx.doi.org/10.7554/eLife.52696 |
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author | Kaur, Gurmeet Burroughs, A Maxwell Iyer, Lakshminarayan M Aravind, L |
author_facet | Kaur, Gurmeet Burroughs, A Maxwell Iyer, Lakshminarayan M Aravind, L |
author_sort | Kaur, Gurmeet |
collection | PubMed |
description | Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically unified, remarkable biological conflict systems preponderantly present in multicellular prokaryotes. These combine thresholding mechanisms utilizing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which vary either by using a reverse transcriptase-dependent diversity-generating system or through a system of acquisition of diverse protein modules, typically in inactive form, from various cellular subsystems. Conciliant lines of evidence indicate their deployment against invasive entities, like viruses, to limit their spread in multicellular/social contexts via physical containment, dominant-negative interactions or apoptosis. These findings argue for both a similar operational ‘grammar’ and shared protein domains in the sensing and limiting of infections during the multiple emergences of multicellularity. |
format | Online Article Text |
id | pubmed-7159879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-71598792020-04-17 Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity Kaur, Gurmeet Burroughs, A Maxwell Iyer, Lakshminarayan M Aravind, L eLife Genetics and Genomics Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically unified, remarkable biological conflict systems preponderantly present in multicellular prokaryotes. These combine thresholding mechanisms utilizing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which vary either by using a reverse transcriptase-dependent diversity-generating system or through a system of acquisition of diverse protein modules, typically in inactive form, from various cellular subsystems. Conciliant lines of evidence indicate their deployment against invasive entities, like viruses, to limit their spread in multicellular/social contexts via physical containment, dominant-negative interactions or apoptosis. These findings argue for both a similar operational ‘grammar’ and shared protein domains in the sensing and limiting of infections during the multiple emergences of multicellularity. eLife Sciences Publications, Ltd 2020-02-26 /pmc/articles/PMC7159879/ /pubmed/32101166 http://dx.doi.org/10.7554/eLife.52696 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) . |
spellingShingle | Genetics and Genomics Kaur, Gurmeet Burroughs, A Maxwell Iyer, Lakshminarayan M Aravind, L Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title_full | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title_fullStr | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title_full_unstemmed | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title_short | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
title_sort | highly regulated, diversifying ntp-dependent biological conflict systems with implications for the emergence of multicellularity |
topic | Genetics and Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159879/ https://www.ncbi.nlm.nih.gov/pubmed/32101166 http://dx.doi.org/10.7554/eLife.52696 |
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