LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggesting LRRK2 also controls immunity. We demonstrate tha...

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Detalles Bibliográficos
Autores principales: Weindel, Chi G, Bell, Samantha L, Vail, Krystal J, West, Kelsi O, Patrick, Kristin L, Watson, Robert O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159881/
https://www.ncbi.nlm.nih.gov/pubmed/32057291
http://dx.doi.org/10.7554/eLife.51071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159881/
https://www.ncbi.nlm.nih.gov/pubmed/32057291
http://dx.doi.org/10.7554/eLife.51071

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