Cargando…
Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8(+) T Cell-Mediated Elimination of Toxoplasma gondii Cysts
We recently found that an invasion of CD8(+) cytotoxic T cells into tissue cysts of Toxoplasma gondii initiates an elimination of the cysts in association with an accumulation of microglia and macrophages. In the present study, we compared mRNA levels for 734 immune-related genes in the brains of in...
Autores principales: | Lutshumba, Jenny, Ochiai, Eri, Sa, Qila, Anand, Namrata, Suzuki, Yasuhiro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159899/ https://www.ncbi.nlm.nih.gov/pubmed/32291349 http://dx.doi.org/10.1128/mSystems.00189-20 |
Ejemplares similares
-
IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii
por: Suzuki, Yasuhiro, et al.
Publicado: (2023) -
Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1
por: Ni, Tao, et al.
Publicado: (2018) -
Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8(+) T cells during the chronic stage of infection
por: Mani, Rajesh, et al.
Publicado: (2023) -
Phagocyte Responses to Protozoan Infection and How Toxoplasma gondii Meets the Challenge
por: Denkers, Eric Y., et al.
Publicado: (2012) -
Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress
por: Guerra, Alfredo J., et al.
Publicado: (2018)