Cryo-EM structure of the Hedgehog release protein Dispatched

The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by secretion of a dually lipid-modified morphogen, Hh, a process dependent on a membrane-integral protein Dispatched. Although...

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Detalles Bibliográficos
Autores principales: Cannac, Fabien, Qi, Chao, Falschlunger, Julia, Hausmann, George, Basler, Konrad, Korkhov, Volodymyr M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159904/
https://www.ncbi.nlm.nih.gov/pubmed/32494603
http://dx.doi.org/10.1126/sciadv.aay7928

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