Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that interleukin (IL)-22, induced by colonization of the gut microbiota, is crucial for the prevention of CDI in human microbi...

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Detalles Bibliográficos
Autores principales: Nagao-Kitamoto, Hiroko, Leslie, Jhansi L., Kitamoto, Sho, Jin, Chunsheng, Thomsson, Kristina A., Gillilland, Merritt G., Kuffa, Peter, Goto, Yoshiyuki, Jenq, Robert R., Ishii, Chiharu, Hirayama, Akiyoshi, Seekatz, Anna M., Martens, Eric C., Eaton, Kathryn A., Kao, John Y., Fukuda, Shinji, Higgins, Peter D. R., Karlsson, Niclas G., Young, Vincent B., Kamada, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160049/
https://www.ncbi.nlm.nih.gov/pubmed/32066975
http://dx.doi.org/10.1038/s41591-020-0764-0

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