Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription

Overactivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare...

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Detalles Bibliográficos
Autores principales: Lucia, Kristin, Wu, Yonghe, Garcia, Jose Monteserin, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Günter K., Theodoropoulou, Marily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160059/
https://www.ncbi.nlm.nih.gov/pubmed/32111982
http://dx.doi.org/10.1038/s41388-020-1223-6

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