Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species

Activation of the Hedgehog (Hh) signaling pathway by mutations within its components drives the growth of several cancers. However, the role of Hh pathway activation in lung cancers has been controversial. Here, we demonstrate that the canonical Hh signaling pathway is activated in lung stroma by Hh...

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Detalles Bibliográficos
Autores principales: Kasiri, Sahba, Chen, Baozhi, Wilson, Alexandra N., Reczek, Annika, Mazambani, Simbarashe, Gadhvi, Jashkaran, Noel, Evan, Marriam, Ummay, Mino, Barbara, Lu, Wei, Girard, Luc, Solis, Luisa M., Luby-Phelps, Katherine, Bishop, Justin, Kim, Jung-Whan, Kim, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160060/
https://www.ncbi.nlm.nih.gov/pubmed/32108165
http://dx.doi.org/10.1038/s41388-020-1224-5

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