Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma

Complex tumor microenvironmental (TME) features influence the outcome of cancer immunotherapy (IO). Here we perform immunogenomic analyses on 67 intratumor sub-regions of a PD-1 inhibitor-resistant melanoma tumor and 2 additional metastases arising over 8 years, to characterize TME interactions. We...

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Detalles Bibliográficos
Autores principales: Mitra, Akash, Andrews, Miles C., Roh, Whijae, De Macedo, Marianna Petaccia, Hudgens, Courtney W., Carapeto, Fernando, Singh, Shailbala, Reuben, Alexandre, Wang, Feng, Mao, Xizeng, Song, Xingzhi, Wani, Khalida, Tippen, Samantha, Ng, Kwok-Shing, Schalck, Aislyn, Sakellariou-Thompson, Donald A., Chen, Eveline, Reddy, Sangeetha M., Spencer, Christine N., Wiesnoski, Diana, Little, Latasha D., Gumbs, Curtis, Cooper, Zachary A., Burton, Elizabeth M., Hwu, Patrick, Davies, Michael A., Zhang, Jianhua, Bernatchez, Chantale, Navin, Nicholas, Sharma, Padmanee, Allison, James P., Wargo, Jennifer A., Yee, Cassian, Tetzlaff, Michael T., Hwu, Wen-Jen, Lazar, Alexander J., Futreal, P. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160105/
https://www.ncbi.nlm.nih.gov/pubmed/32296058
http://dx.doi.org/10.1038/s41467-020-15538-9

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