Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis

Presenilin 1 (PS1) mutations are the most common cause of familial Alzheimer’s disease (FAD). PS1 also plays a role in cellular processes such as calcium homeostasis and autophagy. We hypothesized that mutant presenilins increase cellular vulnerability to stress. We stably expressed human PS1, mutan...

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Detalles Bibliográficos
Autores principales: Rojas-Charry, Liliana, Calero-Martinez, Sergio, Morganti, Claudia, Morciano, Giampaolo, Park, Kyungeun, Hagel, Christian, Marciniak, Stefan J., Glatzel, Markus, Pinton, Paolo, Sepulveda-Falla, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160112/
https://www.ncbi.nlm.nih.gov/pubmed/32296078
http://dx.doi.org/10.1038/s41598-020-63254-7

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