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Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Guanosine 5′-monophosphate reductase (GMPR) is involved in the purine salvage pathway and is conserved throughout evolution. Nonetheless, the GMPR of Trypanosoma brucei (TbGMPR) includes a unique structure known as the cystathionine-β-synthase (CBS) domain, though the role of this domain is not full...

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Detalles Bibliográficos
Autores principales:	Imamura, Akira, Okada, Tetsuya, Mase, Hikaru, Otani, Takuya, Kobayashi, Tomoka, Tamura, Manatsu, Kubata, Bruno Kilunga, Inoue, Katsuaki, Rambo, Robert P., Uchiyama, Susumu, Ishii, Kentaro, Nishimura, Shigenori, Inui, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160140/ https://www.ncbi.nlm.nih.gov/pubmed/32296055 http://dx.doi.org/10.1038/s41467-020-15611-3

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