Cargando…

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are still understudied. Publicly available DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to test if 19p loss is significantly over-repres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lasorsa, Vito Alessandro, Cimmino, Flora, Ognibene, Marzia, Mazzocco, Katia, Erminio, Giovanni, Morini, Martina, Conte, Massimo, Iolascon, Achille, Pezzolo, Annalisa, Capasso, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160145/ https://www.ncbi.nlm.nih.gov/pubmed/32337068 http://dx.doi.org/10.1038/s41525-020-0125-4

Ejemplares similares

Molecular Genetics in Neuroblastoma Prognosis
por: Lerone, Margherita, et al.
Publicado: (2021)

A Targeted Gene Panel for Circulating Tumor DNA Sequencing in Neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma
por: Ognibene, Marzia, et al.
Publicado: (2020)

Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma
por: Ognibene, Marzia, et al.
Publicado: (2020)

FGFR1 is a potential therapeutic target in neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2022)

Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells
por: Degli Esposti, Chiara, et al.
Publicado: (2021)

Neuroblastoma Cell Lines Are Refractory to Genotoxic Drug-Mediated Induction of Ligands for NK Cell-Activating Receptors
por: Veneziani, Irene, et al.
Publicado: (2018)

Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy
por: Ognibene, Marzia, et al.
Publicado: (2019)

Neuroblastoma Patients’ Outcome and Chromosomal Instability
por: Ognibene, Marzia, et al.
Publicado: (2023)

The Over-Expression of E2F3 Might Serve as Prognostic Marker for Neuroblastoma Patients with Stage 4S Disease
por: Parodi, Stefano, et al.
Publicado: (2020)

Multiple Genes with Potential Tumor Suppressive Activity Are Present on Chromosome 10q Loss in Neuroblastoma and Are Associated with Poor Prognosis
por: Ognibene, Marzia, et al.
Publicado: (2023)

Association of PARP1 polymorphisms with response to chemotherapy in patients with high‐risk neuroblastoma
por: Avitabile, Marianna, et al.
Publicado: (2020)

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma
por: Formicola, Daniela, et al.
Publicado: (2016)

High Grade of Amplification of Six Regions on Chromosome 2p in a Neuroblastoma Patient with Very Poor Outcome: The Putative New Oncogene TSSC1
por: Ognibene, Marzia, et al.
Publicado: (2021)

A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma
por: Calabrese, Francesco Maria, et al.
Publicado: (2016)

Kinome multigenic panel identified novel druggable EPHB4‐V871I somatic variant in high‐risk neuroblastoma
por: Andolfo, Immacolata, et al.
Publicado: (2020)

Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma
por: Bonfiglio, Ferdinando, et al.
Publicado: (2022)

CFDP1 is a neuroblastoma susceptibility gene that regulates transcription factors of the noradrenergic cell identity
por: Formicola, Daniela, et al.
Publicado: (2022)

Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
por: Cimmino, Flora, et al.
Publicado: (2015)

Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease
por: Testori, Alessandro, et al.
Publicado: (2019)

Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways
por: Avitabile, Marianna, et al.
Publicado: (2022)

Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4
por: Ognibene, Marzia, et al.
Publicado: (2022)

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
por: Cimmino, Flora, et al.
Publicado: (2019)

CHL1 gene acts as a tumor suppressor in human neuroblastoma
por: Ognibene, Marzia, et al.
Publicado: (2018)

Intratumoral diversity of telomere length in individual neuroblastoma tumors
por: Pezzolo, Annalisa, et al.
Publicado: (2014)

Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations
por: Russo, Roberta, et al.
Publicado: (2020)

Impact of Interleukin-6 –174 G>C Gene Promoter Polymorphism on Neuroblastoma
por: Totaro, Francesca, et al.
Publicado: (2013)

Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression
por: Lasorsa, Vito Alessandro, et al.
Publicado: (2016)

Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome
por: Brandetti, Elisa, et al.
Publicado: (2021)

Immunosuppressive Microenvironment in Neuroblastoma
por: Pistoia, Vito, et al.
Publicado: (2013)

A Simple, Test-Based Method to Control the Overestimation Bias in the Analysis of Potential Prognostic Tumour Markers
por: Ognibene, Marzia, et al.
Publicado: (2023)

Immunohistochemical analysis of PDK1, PHD3 and HIF-1α expression defines the hypoxic status of neuroblastoma tumors
por: Ognibene, Marzia, et al.
Publicado: (2017)

Multiparametric flow cytometry highlights B7-H3 as a novel diagnostic/therapeutic target in GD2neg/low neuroblastoma variants
por: Dondero, Alessandra, et al.
Publicado: (2021)

Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study (‖)
por: Morini, Martina, et al.
Publicado: (2019)

Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells
por: Jemaà, Mohamed, et al.
Publicado: (2020)

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas
por: Cantilena, Sandra, et al.
Publicado: (2011)

Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming
por: Cangelosi, Davide, et al.
Publicado: (2020)

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry
por: De Bernardi, Bruno, et al.
Publicado: (2019)

CD55 is a HIF-2α marker with anti-adhesive and pro-invading properties in neuroblastoma
por: Cimmino, F, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p7kga992fe382e9kbd8rdinv3p