An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases

The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an anal...

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Autores principales: Salvetti, Marco, Battaglia, Mario A., Di Filippo, Massimiliano, Mancardi, Gian Luigi, Mancuso, Michelangelo, Patti, Francesco, Sormani, Maria Pia, Zaratin, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160195/
https://www.ncbi.nlm.nih.gov/pubmed/31858329
http://dx.doi.org/10.1007/s10072-019-04189-4
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author Salvetti, Marco
Battaglia, Mario A.
Di Filippo, Massimiliano
Mancardi, Gian Luigi
Mancuso, Michelangelo
Patti, Francesco
Sormani, Maria Pia
Zaratin, Paola
author_facet Salvetti, Marco
Battaglia, Mario A.
Di Filippo, Massimiliano
Mancardi, Gian Luigi
Mancuso, Michelangelo
Patti, Francesco
Sormani, Maria Pia
Zaratin, Paola
author_sort Salvetti, Marco
collection PubMed
description The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases.
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spelling pubmed-71601952020-04-23 An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases Salvetti, Marco Battaglia, Mario A. Di Filippo, Massimiliano Mancardi, Gian Luigi Mancuso, Michelangelo Patti, Francesco Sormani, Maria Pia Zaratin, Paola Neurol Sci Review Article The complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases. Springer International Publishing 2019-12-19 2020 /pmc/articles/PMC7160195/ /pubmed/31858329 http://dx.doi.org/10.1007/s10072-019-04189-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Salvetti, Marco
Battaglia, Mario A.
Di Filippo, Massimiliano
Mancardi, Gian Luigi
Mancuso, Michelangelo
Patti, Francesco
Sormani, Maria Pia
Zaratin, Paola
An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title_full An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title_fullStr An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title_full_unstemmed An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title_short An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
title_sort “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160195/
https://www.ncbi.nlm.nih.gov/pubmed/31858329
http://dx.doi.org/10.1007/s10072-019-04189-4
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