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Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing
Background: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and/or fast atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with subsequent dilatation, valve regurgitation, and ventricular...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160334/ https://www.ncbi.nlm.nih.gov/pubmed/32328502 http://dx.doi.org/10.3389/fvets.2020.00179 |
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author | Citerni, Carlotta Kirchhoff, Jeppe Olsen, Lisbeth Høier Sattler, Stefan Michael Gentilini, Fabio Forni, Monica Zannoni, Augusta Grunnet, Morten Edvardsson, Nils Bentzen, Bo Hjorth Diness, Jonas Goldin |
author_facet | Citerni, Carlotta Kirchhoff, Jeppe Olsen, Lisbeth Høier Sattler, Stefan Michael Gentilini, Fabio Forni, Monica Zannoni, Augusta Grunnet, Morten Edvardsson, Nils Bentzen, Bo Hjorth Diness, Jonas Goldin |
author_sort | Citerni, Carlotta |
collection | PubMed |
description | Background: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and/or fast atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with subsequent dilatation, valve regurgitation, and ventricular dysfunction with progression to heart failure. Objective: To gain further insight into the myocardial pathophysiological changes induced by right atrial tachypacing (A-TP) in a large animal model. Methods: A total of 28 Landrace pigs were randomized as 14 into AF-induced A-TP group and 14 pigs to control group. AF pigs were tachypaced for 43 ± 4 days until in sustained AF. Functional remodeling was investigated by echocardiography (after cardioversion to sinus rhythm). Structural remodeling was quantified by histological preparations with picrosirius red and immunohistochemical stainings. Results: A-TP resulted in decreased left ventricular ejection fraction (LVEF) accompanied by increased end-diastolic and end-systolic left atrium (LA) volume and area. In addition, A-TP was associated with mitral valve (MV) regurgitation, diastolic dysfunction and increased atrial and ventricular fibrotic extracellular matrix (ECM). Conclusions: A-TP induced AF with concomitant LV systolic and diastolic dysfunction, increased LA volume and area, and atrial and ventricular fibrosis. |
format | Online Article Text |
id | pubmed-7160334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71603342020-04-23 Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing Citerni, Carlotta Kirchhoff, Jeppe Olsen, Lisbeth Høier Sattler, Stefan Michael Gentilini, Fabio Forni, Monica Zannoni, Augusta Grunnet, Morten Edvardsson, Nils Bentzen, Bo Hjorth Diness, Jonas Goldin Front Vet Sci Veterinary Science Background: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and/or fast atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with subsequent dilatation, valve regurgitation, and ventricular dysfunction with progression to heart failure. Objective: To gain further insight into the myocardial pathophysiological changes induced by right atrial tachypacing (A-TP) in a large animal model. Methods: A total of 28 Landrace pigs were randomized as 14 into AF-induced A-TP group and 14 pigs to control group. AF pigs were tachypaced for 43 ± 4 days until in sustained AF. Functional remodeling was investigated by echocardiography (after cardioversion to sinus rhythm). Structural remodeling was quantified by histological preparations with picrosirius red and immunohistochemical stainings. Results: A-TP resulted in decreased left ventricular ejection fraction (LVEF) accompanied by increased end-diastolic and end-systolic left atrium (LA) volume and area. In addition, A-TP was associated with mitral valve (MV) regurgitation, diastolic dysfunction and increased atrial and ventricular fibrotic extracellular matrix (ECM). Conclusions: A-TP induced AF with concomitant LV systolic and diastolic dysfunction, increased LA volume and area, and atrial and ventricular fibrosis. Frontiers Media S.A. 2020-04-09 /pmc/articles/PMC7160334/ /pubmed/32328502 http://dx.doi.org/10.3389/fvets.2020.00179 Text en Copyright © 2020 Citerni, Kirchhoff, Olsen, Sattler, Gentilini, Forni, Zannoni, Grunnet, Edvardsson, Bentzen and Diness. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Citerni, Carlotta Kirchhoff, Jeppe Olsen, Lisbeth Høier Sattler, Stefan Michael Gentilini, Fabio Forni, Monica Zannoni, Augusta Grunnet, Morten Edvardsson, Nils Bentzen, Bo Hjorth Diness, Jonas Goldin Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title | Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title_full | Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title_fullStr | Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title_full_unstemmed | Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title_short | Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing |
title_sort | characterization of atrial and ventricular structural remodeling in a porcine model of atrial fibrillation induced by atrial tachypacing |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160334/ https://www.ncbi.nlm.nih.gov/pubmed/32328502 http://dx.doi.org/10.3389/fvets.2020.00179 |
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