A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo

Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications. Herein, a new class of polyamine-based naphthalimide conjugates 5a-5c, 7a-7b, and 11a-11b...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Jing, Li, Yingguang, Li, Linrong, Yue, Kexin, Liu, Hanfang, Wang, Jiajia, Xi, Zhuoqing, Shi, Man, Zhao, Sihan, Ma, Qi, Liu, Sitong, Guo, Shudi, Liu, Jianing, Hou, Lili, Wang, Chaojie, Wang, Peng George, Tian, Zhiyong, Xie, Songqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160362/
https://www.ncbi.nlm.nih.gov/pubmed/32328475
http://dx.doi.org/10.3389/fchem.2020.00166

Ejemplares similares

Ejemplares similares