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Integrating Ligand and Target-Driven Based Virtual Screening Approaches With in vitro Human Cell Line Models and Time-Resolved Fluorescence Resonance Energy Transfer Assay to Identify Novel Hit Compounds Against BCL-2

Antiapoptotic members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins are one of the overexpressed proteins in cancer cells that are oncogenic targets. As such, targeting of BCL-2 family proteins raises hopes for new therapeutic discoveries. Thus, we used multistep screening and filtering appr...

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Detalles Bibliográficos
Autores principales:	Tutumlu, Gurbet, Dogan, Berna, Avsar, Timucin, Orhan, Muge Didem, Calis, Seyma, Durdagi, Serdar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160371/ https://www.ncbi.nlm.nih.gov/pubmed/32328476 http://dx.doi.org/10.3389/fchem.2020.00167

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