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Neuropeptides in gut-brain axis and their influence on host immunity and stress
In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In additio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Research Network of Computational and Structural Biotechnology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160382/ https://www.ncbi.nlm.nih.gov/pubmed/32322366 http://dx.doi.org/10.1016/j.csbj.2020.02.018 |
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author | Wei, Pingli Keller, Caitlin Li, Lingjun |
author_facet | Wei, Pingli Keller, Caitlin Li, Lingjun |
author_sort | Wei, Pingli |
collection | PubMed |
description | In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In addition to being critical to communication from the brain in the nervous systems, neuropeptides actively regulate immune functions in the gut in both direct and indirect ways, allowing for communication between the immune and nervous systems. In this mini review, we discuss the role of several neuropeptides, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), corticotropin-releasing hormone (CRH) and phoenixin (PNX), in the gut-brain axis and summarize their functions in immunity and stress. We choose these neuropeptides to highlight the diversity of peptide communication in the gut-brain axis. |
format | Online Article Text |
id | pubmed-7160382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71603822020-04-22 Neuropeptides in gut-brain axis and their influence on host immunity and stress Wei, Pingli Keller, Caitlin Li, Lingjun Comput Struct Biotechnol J Review Article In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In addition to being critical to communication from the brain in the nervous systems, neuropeptides actively regulate immune functions in the gut in both direct and indirect ways, allowing for communication between the immune and nervous systems. In this mini review, we discuss the role of several neuropeptides, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), corticotropin-releasing hormone (CRH) and phoenixin (PNX), in the gut-brain axis and summarize their functions in immunity and stress. We choose these neuropeptides to highlight the diversity of peptide communication in the gut-brain axis. Research Network of Computational and Structural Biotechnology 2020-03-04 /pmc/articles/PMC7160382/ /pubmed/32322366 http://dx.doi.org/10.1016/j.csbj.2020.02.018 Text en © 2020 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Wei, Pingli Keller, Caitlin Li, Lingjun Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title | Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title_full | Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title_fullStr | Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title_full_unstemmed | Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title_short | Neuropeptides in gut-brain axis and their influence on host immunity and stress |
title_sort | neuropeptides in gut-brain axis and their influence on host immunity and stress |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160382/ https://www.ncbi.nlm.nih.gov/pubmed/32322366 http://dx.doi.org/10.1016/j.csbj.2020.02.018 |
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