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Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI
BACKGROUND: Metastatic osteosarcoma with direct cardiac involvement is an exceptionally rare finding. Reliable detection of cardiac metastases is known to be crucial for patients therapy and prognosis. CASE SUMMARY: In a 10-year-old boy affected by osteosarcoma of the left femur, a baseline Fluorine...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160384/ https://www.ncbi.nlm.nih.gov/pubmed/32322327 http://dx.doi.org/10.1016/j.radcr.2020.03.019 |
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author | Linder, Verena Fritscher, Torsten Hammon, Matthias Schroth, Michael Schmidt, Wolfgang Uder, Michael Rompel, Oliver |
author_facet | Linder, Verena Fritscher, Torsten Hammon, Matthias Schroth, Michael Schmidt, Wolfgang Uder, Michael Rompel, Oliver |
author_sort | Linder, Verena |
collection | PubMed |
description | BACKGROUND: Metastatic osteosarcoma with direct cardiac involvement is an exceptionally rare finding. Reliable detection of cardiac metastases is known to be crucial for patients therapy and prognosis. CASE SUMMARY: In a 10-year-old boy affected by osteosarcoma of the left femur, a baseline Fluorine-18-fluorodeoxy-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed to assess the full extent of disease. Whole-body scan detected numerous bone metastases together with a single pulmonary metastasis. Moreover, increased tracer uptake was observed in the intracavitary right cardiac ventricle in the position of a subtle spot of calcification. Because of nondetectability of a cavitary lesion on echocardiography, cardiac magnetic resonance imaging (CMRI) examination was performed to evaluate cardiac (18)F-FDG PET/CT finding. CMRI revealed a small nodule in the right ventricle attached to the trabeculae, highly suspicious of a direct cardiac metastasis. After 4 cycles of chemotherapy, complete regression of tracer uptake of the lesion was observed on a follow-up (18)F-FDG PET/CT scan. CONCLUSION: CMRI is able to detect even small, clinically asymptomatic cardiac metastases in young patients affected by osteosarcoma. |
format | Online Article Text |
id | pubmed-7160384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71603842020-04-22 Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI Linder, Verena Fritscher, Torsten Hammon, Matthias Schroth, Michael Schmidt, Wolfgang Uder, Michael Rompel, Oliver Radiol Case Rep Oncology BACKGROUND: Metastatic osteosarcoma with direct cardiac involvement is an exceptionally rare finding. Reliable detection of cardiac metastases is known to be crucial for patients therapy and prognosis. CASE SUMMARY: In a 10-year-old boy affected by osteosarcoma of the left femur, a baseline Fluorine-18-fluorodeoxy-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed to assess the full extent of disease. Whole-body scan detected numerous bone metastases together with a single pulmonary metastasis. Moreover, increased tracer uptake was observed in the intracavitary right cardiac ventricle in the position of a subtle spot of calcification. Because of nondetectability of a cavitary lesion on echocardiography, cardiac magnetic resonance imaging (CMRI) examination was performed to evaluate cardiac (18)F-FDG PET/CT finding. CMRI revealed a small nodule in the right ventricle attached to the trabeculae, highly suspicious of a direct cardiac metastasis. After 4 cycles of chemotherapy, complete regression of tracer uptake of the lesion was observed on a follow-up (18)F-FDG PET/CT scan. CONCLUSION: CMRI is able to detect even small, clinically asymptomatic cardiac metastases in young patients affected by osteosarcoma. Elsevier 2020-04-13 /pmc/articles/PMC7160384/ /pubmed/32322327 http://dx.doi.org/10.1016/j.radcr.2020.03.019 Text en © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Linder, Verena Fritscher, Torsten Hammon, Matthias Schroth, Michael Schmidt, Wolfgang Uder, Michael Rompel, Oliver Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title | Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title_full | Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title_fullStr | Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title_full_unstemmed | Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title_short | Small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac MRI |
title_sort | small direct right ventricular cardiac metastasis of osteosarcoma in a 10-year-old boy affirmed by cardiac mri |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160384/ https://www.ncbi.nlm.nih.gov/pubmed/32322327 http://dx.doi.org/10.1016/j.radcr.2020.03.019 |
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