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Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It
Proteins are molecular machines with the capacity to perform diverse physical work as response to signals from the environment. Proteins may be found as monomers or polymers, two states that represent an important subset of protein interactions and generate considerable functional diversity, leading...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Applied Systems srl
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160546/ https://www.ncbi.nlm.nih.gov/pubmed/32309550 http://dx.doi.org/10.15190/d.2014.13 |
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author | Hammel, Ilan Meilijson, Isaac |
author_facet | Hammel, Ilan Meilijson, Isaac |
author_sort | Hammel, Ilan |
collection | PubMed |
description | Proteins are molecular machines with the capacity to perform diverse physical work as response to signals from the environment. Proteins may be found as monomers or polymers, two states that represent an important subset of protein interactions and generate considerable functional diversity, leading to regulatory mechanisms closely akin to decision-making in service systems. Polymerization is not unique to proteins. Other cell compartments (e.g. secretory granules) or tissue states (e.g. miniature end plate potential) are associated with polymerization of some sort, leading to information transport. This data-processing mechanism has similarities with (and led us to the investigation of) granule homotypic polymerization kinetics. Using information theory, we demonstrate the role played by the heterogeneity induced by polymerization: granule size distribution and the stealthy machine behind granule life cycle increase system entropy, which modulates the source/receiver potential that affects communication between the cell and its environment. The granule inventory management by the same nano-machine is discussed. |
format | Online Article Text |
id | pubmed-7160546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Applied Systems srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-71605462020-04-17 Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It Hammel, Ilan Meilijson, Isaac Discoveries (Craiova) Original Article Proteins are molecular machines with the capacity to perform diverse physical work as response to signals from the environment. Proteins may be found as monomers or polymers, two states that represent an important subset of protein interactions and generate considerable functional diversity, leading to regulatory mechanisms closely akin to decision-making in service systems. Polymerization is not unique to proteins. Other cell compartments (e.g. secretory granules) or tissue states (e.g. miniature end plate potential) are associated with polymerization of some sort, leading to information transport. This data-processing mechanism has similarities with (and led us to the investigation of) granule homotypic polymerization kinetics. Using information theory, we demonstrate the role played by the heterogeneity induced by polymerization: granule size distribution and the stealthy machine behind granule life cycle increase system entropy, which modulates the source/receiver potential that affects communication between the cell and its environment. The granule inventory management by the same nano-machine is discussed. Applied Systems srl 2014-09-02 /pmc/articles/PMC7160546/ /pubmed/32309550 http://dx.doi.org/10.15190/d.2014.13 Text en Copyright: © 2014, Hammel et al. and Applied Systems http://creativecommons.org/licenses/by/4.0/ This article is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Article Hammel, Ilan Meilijson, Isaac Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title | Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title_full | Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title_fullStr | Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title_full_unstemmed | Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title_short | Quantal Basis of Secretory Granule Biogenesis and Inventory Maintenance: the Surreptitious Nano-machine Behind It |
title_sort | quantal basis of secretory granule biogenesis and inventory maintenance: the surreptitious nano-machine behind it |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160546/ https://www.ncbi.nlm.nih.gov/pubmed/32309550 http://dx.doi.org/10.15190/d.2014.13 |
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