Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation

BACKGROUND & AIMS: Claudin-7 (Cldn7) is a tight junction (TJ) membrane protein located at the apical TJ and basolateral side of intestinal epithelial cells. Deletion of Cldn7 by gene targeting leads to the inflammatory bowel disease–like phenotype in mice, which includes weight loss, diarrhea, m...

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Detalles Bibliográficos
Autores principales: Xing, Tiaosi, Benderman, Lesley Jasmine, Sabu, Stephiya, Parker, Joel, Yang, Jeffrey, Lu, Qun, Ding, Lei, Chen, Yan-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160575/
https://www.ncbi.nlm.nih.gov/pubmed/31874254
http://dx.doi.org/10.1016/j.jcmgh.2019.12.005

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