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S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due to a red...

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Detalles Bibliográficos
Autores principales:	Cohen, Taylor S., Boland, Michelle L., Boland, Brandon B., Takahashi, Virginia, Tovchigrechko, Andrey, Lee, Young, Wilde, Aimee D., Mazaitis, Mark J., Jones-Nelson, Omari, Tkaczyk, Christine, Raja, Rajiv, Stover, C. Kendall, Sellman, Bret R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160668/ https://www.ncbi.nlm.nih.gov/pubmed/29490278 http://dx.doi.org/10.1016/j.celrep.2018.02.027

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