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LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of lethality when released extracellularly during sepsis. The major source of circulating HMGB1 in sepsis is hepatocytes. However, the mechanism of HMGB1 release of hepatocytes during sepsis is not very clear. W...

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Detalles Bibliográficos
Autores principales:	Li, Wenbo, Deng, Meihong, Loughran, Patricia A., Yang, Muqing, Lin, Minjie, Yang, Chenxuan, Gao, Wentao, Jin, Shuqing, Li, Shilai, Cai, Jingjing, Lu, Ben, Billiar, Timothy R., Scott, Melanie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160675/ https://www.ncbi.nlm.nih.gov/pubmed/32328059 http://dx.doi.org/10.3389/fimmu.2020.00229

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