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Mycobiome in the Gut: A Multiperspective Review

Human gut is home to a diverse and complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi, and other microorganisms that have an undisputable role in maintaining good health for the host. Studies on the interplay between microbiota in the gut and various human diseases remain t...

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Autores principales: Chin, Voon Kin, Yong, Voon Chen, Chong, Pei Pei, Amin Nordin, Syafinaz, Basir, Rusliza, Abdullah, Maha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160717/
https://www.ncbi.nlm.nih.gov/pubmed/32322167
http://dx.doi.org/10.1155/2020/9560684
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author Chin, Voon Kin
Yong, Voon Chen
Chong, Pei Pei
Amin Nordin, Syafinaz
Basir, Rusliza
Abdullah, Maha
author_facet Chin, Voon Kin
Yong, Voon Chen
Chong, Pei Pei
Amin Nordin, Syafinaz
Basir, Rusliza
Abdullah, Maha
author_sort Chin, Voon Kin
collection PubMed
description Human gut is home to a diverse and complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi, and other microorganisms that have an undisputable role in maintaining good health for the host. Studies on the interplay between microbiota in the gut and various human diseases remain the key focus among many researchers. Nevertheless, advances in sequencing technologies and computational biology have helped us to identify a diversity of fungal community that reside in the gut known as the mycobiome. Although studies on gut mycobiome are still in its infancy, numerous sources have reported its potential role in host homeostasis and disease development. Nonetheless, the actual mechanism of its involvement remains largely unknown and underexplored. Thus, in this review, we attempt to discuss the recent advances in gut mycobiome research from multiple perspectives. This includes understanding the composition of fungal communities in the gut and the involvement of gut mycobiome in host immunity and gut-brain axis. Further, we also discuss on multibiome interactions in the gut with emphasis on fungi-bacteria interaction and the influence of diet in shaping gut mycobiome composition. This review also highlights the relation between fungal metabolites and gut mycobiota in human homeostasis and the role of gut mycobiome in various human diseases. This multiperspective review on gut mycobiome could perhaps shed new light for future studies in the mycobiome research area.
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spelling pubmed-71607172020-04-22 Mycobiome in the Gut: A Multiperspective Review Chin, Voon Kin Yong, Voon Chen Chong, Pei Pei Amin Nordin, Syafinaz Basir, Rusliza Abdullah, Maha Mediators Inflamm Review Article Human gut is home to a diverse and complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi, and other microorganisms that have an undisputable role in maintaining good health for the host. Studies on the interplay between microbiota in the gut and various human diseases remain the key focus among many researchers. Nevertheless, advances in sequencing technologies and computational biology have helped us to identify a diversity of fungal community that reside in the gut known as the mycobiome. Although studies on gut mycobiome are still in its infancy, numerous sources have reported its potential role in host homeostasis and disease development. Nonetheless, the actual mechanism of its involvement remains largely unknown and underexplored. Thus, in this review, we attempt to discuss the recent advances in gut mycobiome research from multiple perspectives. This includes understanding the composition of fungal communities in the gut and the involvement of gut mycobiome in host immunity and gut-brain axis. Further, we also discuss on multibiome interactions in the gut with emphasis on fungi-bacteria interaction and the influence of diet in shaping gut mycobiome composition. This review also highlights the relation between fungal metabolites and gut mycobiota in human homeostasis and the role of gut mycobiome in various human diseases. This multiperspective review on gut mycobiome could perhaps shed new light for future studies in the mycobiome research area. Hindawi 2020-04-04 /pmc/articles/PMC7160717/ /pubmed/32322167 http://dx.doi.org/10.1155/2020/9560684 Text en Copyright © 2020 Voon Kin Chin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chin, Voon Kin
Yong, Voon Chen
Chong, Pei Pei
Amin Nordin, Syafinaz
Basir, Rusliza
Abdullah, Maha
Mycobiome in the Gut: A Multiperspective Review
title Mycobiome in the Gut: A Multiperspective Review
title_full Mycobiome in the Gut: A Multiperspective Review
title_fullStr Mycobiome in the Gut: A Multiperspective Review
title_full_unstemmed Mycobiome in the Gut: A Multiperspective Review
title_short Mycobiome in the Gut: A Multiperspective Review
title_sort mycobiome in the gut: a multiperspective review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160717/
https://www.ncbi.nlm.nih.gov/pubmed/32322167
http://dx.doi.org/10.1155/2020/9560684
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