DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment

Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have de...

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Autores principales: Zhu, Hongming, Zhu, He, Tian, Miao, Wang, Dongying, He, Jiaxing, Xu, Tianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160865/
https://www.ncbi.nlm.nih.gov/pubmed/32328088
http://dx.doi.org/10.3389/fgene.2020.00347
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author Zhu, Hongming
Zhu, He
Tian, Miao
Wang, Dongying
He, Jiaxing
Xu, Tianmin
author_facet Zhu, Hongming
Zhu, He
Tian, Miao
Wang, Dongying
He, Jiaxing
Xu, Tianmin
author_sort Zhu, Hongming
collection PubMed
description Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have demonstrated the importance of DNA methylation and hydroxymethylation in specific genes in the progression of cervical cancer. Determining the methylation and hydroxymethylation profiles of these genes will help in the early prevention and diagnosis, monitoring recurrence, prognosis, and treatment of patients with cervical cancer. In this review, we focus on the significance of aberrant DNA methylation and hydroxymethylation in cervical cancer and the use of these epigenetic signatures in clinical settings.
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spelling pubmed-71608652020-04-23 DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment Zhu, Hongming Zhu, He Tian, Miao Wang, Dongying He, Jiaxing Xu, Tianmin Front Genet Genetics Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have demonstrated the importance of DNA methylation and hydroxymethylation in specific genes in the progression of cervical cancer. Determining the methylation and hydroxymethylation profiles of these genes will help in the early prevention and diagnosis, monitoring recurrence, prognosis, and treatment of patients with cervical cancer. In this review, we focus on the significance of aberrant DNA methylation and hydroxymethylation in cervical cancer and the use of these epigenetic signatures in clinical settings. Frontiers Media S.A. 2020-04-09 /pmc/articles/PMC7160865/ /pubmed/32328088 http://dx.doi.org/10.3389/fgene.2020.00347 Text en Copyright © 2020 Zhu, Zhu, Tian, Wang, He and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhu, Hongming
Zhu, He
Tian, Miao
Wang, Dongying
He, Jiaxing
Xu, Tianmin
DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title_full DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title_fullStr DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title_full_unstemmed DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title_short DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
title_sort dna methylation and hydroxymethylation in cervical cancer: diagnosis, prognosis and treatment
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160865/
https://www.ncbi.nlm.nih.gov/pubmed/32328088
http://dx.doi.org/10.3389/fgene.2020.00347
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