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Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis

BACKGROUND: Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reduction of ω-6 to ω-3 FA ratio, under the same dietary conditions, would mitigate...

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Detalles Bibliográficos
Autores principales:	Kimmerling, Kelly A., Oswald, Sara J., Huebner, Janet L., Little, Dianne, Kraus, Virginia B., Kang, Jing X., Wu, Chia-Lung, Guilak, Farshid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160898/ https://www.ncbi.nlm.nih.gov/pubmed/32295649 http://dx.doi.org/10.1186/s13075-020-02170-7

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