Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the formation of large tissue destructive lesions in the...

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Detalles Bibliográficos
Autores principales: Tsymala, Irina, Nigritinou, Magdalini, Zeka, Bleranda, Schulz, Rouven, Niederschick, Felix, Matković, Mia, Bauer, Isabel J., Szalay, Michael, Schanda, Kathrin, Lerch, Magdalena, Misu, Tatsuro, Fujihara, Kazuo, Bennett, Jeffrey L., Dahle, Charlotte, Pache, Florence, Rommer, Paulus, Leutmezer, Fritz, Illes, Zsolt, Leite, Maria Isabel, Palace, Jacqueline, Scholze, Petra, Reindl, Markus, Lassmann, Hans, Bradl, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160927/
https://www.ncbi.nlm.nih.gov/pubmed/32293546
http://dx.doi.org/10.1186/s40478-020-00920-x

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