Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...

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Detalles Bibliográficos
Autores principales: Zhang, Baoyuan, Lyu, Junfang, Yang, Eun Ju, Liu, Yifan, Wu, Changjie, Pardeshi, Lakhansing, Tan, Kaeling, Chen, Qiang, Xu, Xiaoling, Deng, Chu-Xia, Shim, Joong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161709/
https://www.ncbi.nlm.nih.gov/pubmed/32322466
http://dx.doi.org/10.1016/j.apsb.2019.08.008

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