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Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids
The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162524/ https://www.ncbi.nlm.nih.gov/pubmed/32251477 http://dx.doi.org/10.1371/journal.pgen.1008680 |
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author | Langdon, Quinn K. Peris, David Eizaguirre, Juan I. Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María E. Lopes, Christian A. Libkind, Diego Hittinger, Chris Todd |
author_facet | Langdon, Quinn K. Peris, David Eizaguirre, Juan I. Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María E. Lopes, Christian A. Libkind, Diego Hittinger, Chris Todd |
author_sort | Langdon, Quinn K. |
collection | PubMed |
description | The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history. |
format | Online Article Text |
id | pubmed-7162524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-71625242020-04-24 Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids Langdon, Quinn K. Peris, David Eizaguirre, Juan I. Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María E. Lopes, Christian A. Libkind, Diego Hittinger, Chris Todd PLoS Genet Research Article The wild, cold-adapted parent of hybrid lager-brewing yeasts, Saccharomyces eubayanus, has a complex and understudied natural history. The exploration of this diversity can be used both to develop new brewing applications and to enlighten our understanding of the dynamics of yeast evolution in the wild. Here, we integrate whole genome sequence and phenotypic data of 200 S. eubayanus strains, the largest collection known to date. S. eubayanus has a multilayered population structure, consisting of two major populations that are further structured into six subpopulations. Four of these subpopulations are found exclusively in the Patagonian region of South America; one is found predominantly in Patagonia and sparsely in Oceania and North America; and one is specific to the Holarctic ecozone. Plant host associations differed between subpopulations and between S. eubayanus and its sister species, Saccharomyces uvarum. S. eubayanus is most abundant and genetically diverse in northern Patagonia, where some locations harbor more genetic diversity than is found outside of South America, suggesting that northern Patagonia east of the Andes was a glacial refugium for this species. All but one subpopulation shows isolation-by-distance, and gene flow between subpopulations is low. However, there are strong signals of ancient and recent outcrossing, including two admixed lineages, one that is sympatric with and one that is mostly isolated from its parental populations. Using our extensive biogeographical data, we build a robust model that predicts all known and a handful of additional regions of the globe that are climatically suitable for S. eubayanus, including Europe where host accessibility and competitive exclusion by other Saccharomyces species may explain its continued elusiveness. We conclude that this industrially relevant species has rich natural diversity with many factors contributing to its complex distribution and natural history. Public Library of Science 2020-04-06 /pmc/articles/PMC7162524/ /pubmed/32251477 http://dx.doi.org/10.1371/journal.pgen.1008680 Text en © 2020 Langdon et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Langdon, Quinn K. Peris, David Eizaguirre, Juan I. Opulente, Dana A. Buh, Kelly V. Sylvester, Kayla Jarzyna, Martin Rodríguez, María E. Lopes, Christian A. Libkind, Diego Hittinger, Chris Todd Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title | Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title_full | Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title_fullStr | Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title_full_unstemmed | Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title_short | Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
title_sort | postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162524/ https://www.ncbi.nlm.nih.gov/pubmed/32251477 http://dx.doi.org/10.1371/journal.pgen.1008680 |
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