Saliva: potential diagnostic value and transmission of 2019-nCoV

2019-nCoV epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now. Saliva, a biofluid largely generated from salivary glands in oral cavity, has been reported 2019-nCoV nucleic acid positive. Besides lungs, salivary glands and tongue are possibly anoth...

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Autores principales: Xu, Ruoshi, Cui, Bomiao, Duan, Xiaobo, Zhang, Ping, Zhou, Xuedong, Yuan, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162686/
https://www.ncbi.nlm.nih.gov/pubmed/32300101
http://dx.doi.org/10.1038/s41368-020-0080-z
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author Xu, Ruoshi
Cui, Bomiao
Duan, Xiaobo
Zhang, Ping
Zhou, Xuedong
Yuan, Quan
author_facet Xu, Ruoshi
Cui, Bomiao
Duan, Xiaobo
Zhang, Ping
Zhou, Xuedong
Yuan, Quan
author_sort Xu, Ruoshi
collection PubMed
description 2019-nCoV epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now. Saliva, a biofluid largely generated from salivary glands in oral cavity, has been reported 2019-nCoV nucleic acid positive. Besides lungs, salivary glands and tongue are possibly another hosts of 2019-nCoV due to expression of ACE2. Close contact or short-range transmission of infectious saliva droplets is a primary mode for 2019-nCoV to disseminate as claimed by WHO, while long-distance saliva aerosol transmission is highly environment dependent within indoor space with aerosol-generating procedures such as dental practice. So far, no direct evidence has been found that 2019-nCoV is vital in air flow for long time. Therefore, to prevent formation of infectious saliva droplets, to thoroughly disinfect indoor air and to block acquisition of saliva droplets could slow down 2019-nCoV dissemination. This review summarizes diagnostic value of saliva for 2019-nCoV, possibly direct invasion into oral tissues, and close contact transmission of 2019-nCoV by saliva droplets, expecting to contribute to 2019-nCoV epidemic control.
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spelling pubmed-71626862020-04-17 Saliva: potential diagnostic value and transmission of 2019-nCoV Xu, Ruoshi Cui, Bomiao Duan, Xiaobo Zhang, Ping Zhou, Xuedong Yuan, Quan Int J Oral Sci Review Article 2019-nCoV epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now. Saliva, a biofluid largely generated from salivary glands in oral cavity, has been reported 2019-nCoV nucleic acid positive. Besides lungs, salivary glands and tongue are possibly another hosts of 2019-nCoV due to expression of ACE2. Close contact or short-range transmission of infectious saliva droplets is a primary mode for 2019-nCoV to disseminate as claimed by WHO, while long-distance saliva aerosol transmission is highly environment dependent within indoor space with aerosol-generating procedures such as dental practice. So far, no direct evidence has been found that 2019-nCoV is vital in air flow for long time. Therefore, to prevent formation of infectious saliva droplets, to thoroughly disinfect indoor air and to block acquisition of saliva droplets could slow down 2019-nCoV dissemination. This review summarizes diagnostic value of saliva for 2019-nCoV, possibly direct invasion into oral tissues, and close contact transmission of 2019-nCoV by saliva droplets, expecting to contribute to 2019-nCoV epidemic control. Nature Publishing Group UK 2020-04-17 /pmc/articles/PMC7162686/ /pubmed/32300101 http://dx.doi.org/10.1038/s41368-020-0080-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Xu, Ruoshi
Cui, Bomiao
Duan, Xiaobo
Zhang, Ping
Zhou, Xuedong
Yuan, Quan
Saliva: potential diagnostic value and transmission of 2019-nCoV
title Saliva: potential diagnostic value and transmission of 2019-nCoV
title_full Saliva: potential diagnostic value and transmission of 2019-nCoV
title_fullStr Saliva: potential diagnostic value and transmission of 2019-nCoV
title_full_unstemmed Saliva: potential diagnostic value and transmission of 2019-nCoV
title_short Saliva: potential diagnostic value and transmission of 2019-nCoV
title_sort saliva: potential diagnostic value and transmission of 2019-ncov
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162686/
https://www.ncbi.nlm.nih.gov/pubmed/32300101
http://dx.doi.org/10.1038/s41368-020-0080-z
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AT zhouxuedong salivapotentialdiagnosticvalueandtransmissionof2019ncov
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