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Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models

The gut microbiota has a great impact on the host immune systems. Recent evidence suggests that the maternal gut microbiota affects the immune systems of offspring. Metabolites produced by the gut microbiota play crucial roles in the immune system. Previous studies have also revealed that metabolite...

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Autores principales: NAKAJIMA, Akihito, HABU, Sonoko, KASAI, Masataka, OKUMURA, Ko, ISHIKAWA, Dai, SHIBUYA, Tomoyoshi, KOBAYASHI, Osamu, OSADA, Taro, OHKUSA, Toshifumi, WATANABE, Sumio, NAGAHARA, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162694/
https://www.ncbi.nlm.nih.gov/pubmed/32328398
http://dx.doi.org/10.12938/bmfh.19-013
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author NAKAJIMA, Akihito
HABU, Sonoko
KASAI, Masataka
OKUMURA, Ko
ISHIKAWA, Dai
SHIBUYA, Tomoyoshi
KOBAYASHI, Osamu
OSADA, Taro
OHKUSA, Toshifumi
WATANABE, Sumio
NAGAHARA, Akihito
author_facet NAKAJIMA, Akihito
HABU, Sonoko
KASAI, Masataka
OKUMURA, Ko
ISHIKAWA, Dai
SHIBUYA, Tomoyoshi
KOBAYASHI, Osamu
OSADA, Taro
OHKUSA, Toshifumi
WATANABE, Sumio
NAGAHARA, Akihito
author_sort NAKAJIMA, Akihito
collection PubMed
description The gut microbiota has a great impact on the host immune systems. Recent evidence suggests that the maternal gut microbiota affects the immune systems of offspring. Metabolites produced by the gut microbiota play crucial roles in the immune system. Previous studies have also revealed that metabolites such as short-chain fatty acids (SCFAs) and the aryl hydrocarbon receptor (AhR) ligands are involved in host health and diseases. Great progress has been made in understanding the roles of diet-derived SCFAs in the offspring’s immune system. The findings to date raise the possibility that maternal dietary soluble fiber intake may play a role in the development of the offspring’s systemic immune response. In this review, we summarize the present knowledge and discuss future therapeutic possibilities for using dietary soluble fiber intake against inflammatory diseases.
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spelling pubmed-71626942020-04-23 Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models NAKAJIMA, Akihito HABU, Sonoko KASAI, Masataka OKUMURA, Ko ISHIKAWA, Dai SHIBUYA, Tomoyoshi KOBAYASHI, Osamu OSADA, Taro OHKUSA, Toshifumi WATANABE, Sumio NAGAHARA, Akihito Biosci Microbiota Food Health Review The gut microbiota has a great impact on the host immune systems. Recent evidence suggests that the maternal gut microbiota affects the immune systems of offspring. Metabolites produced by the gut microbiota play crucial roles in the immune system. Previous studies have also revealed that metabolites such as short-chain fatty acids (SCFAs) and the aryl hydrocarbon receptor (AhR) ligands are involved in host health and diseases. Great progress has been made in understanding the roles of diet-derived SCFAs in the offspring’s immune system. The findings to date raise the possibility that maternal dietary soluble fiber intake may play a role in the development of the offspring’s systemic immune response. In this review, we summarize the present knowledge and discuss future therapeutic possibilities for using dietary soluble fiber intake against inflammatory diseases. BMFH Press 2020-01-25 2020 /pmc/articles/PMC7162694/ /pubmed/32328398 http://dx.doi.org/10.12938/bmfh.19-013 Text en ©2020 BMFH Press This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
NAKAJIMA, Akihito
HABU, Sonoko
KASAI, Masataka
OKUMURA, Ko
ISHIKAWA, Dai
SHIBUYA, Tomoyoshi
KOBAYASHI, Osamu
OSADA, Taro
OHKUSA, Toshifumi
WATANABE, Sumio
NAGAHARA, Akihito
Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title_full Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title_fullStr Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title_full_unstemmed Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title_short Impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
title_sort impact of maternal dietary gut microbial metabolites on an offspring’s systemic immune response in mouse models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162694/
https://www.ncbi.nlm.nih.gov/pubmed/32328398
http://dx.doi.org/10.12938/bmfh.19-013
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