An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions

β-Hydroxy-α-amino acids (βH-AAs) are key components of many bioactive molecules as well as exist as specialised metabolites. Among these βH-AAs, 4-fluorothreonine (4-FT) is the only naturally occurring fluorinated AA discovered thus far. Here we report overexpression and biochemical characterisation...

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Detalles Bibliográficos
Autores principales: Wu, Linrui, Tong, Ming Him, Raab, Andrea, Fang, Qing, Wang, Shan, Kyeremeh, Kwaku, Yu, Yi, Deng, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Biotechnologically Relevant Enzymes and Proteins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162832/
https://www.ncbi.nlm.nih.gov/pubmed/32140842
http://dx.doi.org/10.1007/s00253-020-10497-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162832/
https://www.ncbi.nlm.nih.gov/pubmed/32140842
http://dx.doi.org/10.1007/s00253-020-10497-z

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