Non-peptidyl small molecule, adenosine, 5′-Se-methyl-5′-seleno-, 2′,3′-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Lepr(db/db) mice

The pathophysiology of type 2 diabetes mellitus (T2D) is characterized by reduced or absent insulin receptor (INSR) responsiveness to its ligand, elevated hepatic glucose output and impaired glucose uptake in peripheral tissues, particularly skeletal muscle. Treatments to reduce hyperglycemia and re...

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Detalles Bibliográficos
Autores principales: Lan, Zi-Jian, Lei, Zhenmin, Yiannikouris, Alexandros, Yerramreddy, Thirupathi Reddy, Li, Xian, Kincaid, Hayley, Eastridge, Katie, Gadberry, Hannah, Power, Chloe, Xiao, Rijin, Lei, Lei, Seale, Olivia, Dawson, Karl, Power, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162833/
https://www.ncbi.nlm.nih.gov/pubmed/31378829
http://dx.doi.org/10.1007/s00018-019-03249-4

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