Cargando…

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and Other Neurodegenerative Disorders

Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid X receptor (RXR) bind in promotor of target genes to PPAR response elements (PPREs) and act as a potent transcription...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wójtowicz, Sylwia, Strosznajder, Anna K., Jeżyna, Mieszko, Strosznajder, Joanna B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162839/ https://www.ncbi.nlm.nih.gov/pubmed/32170673 http://dx.doi.org/10.1007/s11064-020-02993-5

Ejemplares similares

Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy
por: Strosznajder, Anna K., et al.
Publicado: (2020)

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
por: Jęśko, Henryk, et al.
Publicado: (2016)

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
por: Motyl, J., et al.
Publicado: (2017)

Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease
por: Jęśko, Henryk, et al.
Publicado: (2020)

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders
por: Czubowicz, Kinga, et al.
Publicado: (2019)

Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer’s Disease
por: Cieślik, Magdalena, et al.
Publicado: (2019)

Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease
por: Motyl, Joanna A., et al.
Publicado: (2021)

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
por: Czapski, Grzegorz A., et al.
Publicado: (2015)

Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca(2+) Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders
por: Czapski, Grzegorz A., et al.
Publicado: (2020)

Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival
por: Czubowicz, Kinga, et al.
Publicado: (2014)

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity
por: Wencel, Przemysław L., et al.
Publicado: (2017)

Lipoxygenases and Poly(ADP-Ribose) Polymerase in Amyloid Beta Cytotoxicity
por: Strosznajder, Joanna B., et al.
Publicado: (2011)

Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders
por: Kaur, Gagandeep, et al.
Publicado: (2022)

Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate
por: Czubowicz, Kinga, et al.
Publicado: (2014)

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
por: Cieślik, Magdalena, et al.
Publicado: (2015)

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease
por: Jęśko, Henryk, et al.
Publicado: (2018)

Melatonin in Alzheimer's disease and other neurodegenerative disorders
por: Srinivasan, V, et al.
Publicado: (2006)

Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration
por: Wieczorek, Iga, et al.
Publicado: (2023)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Nanoimaging for Molecular Pharmaceutics of Alzheimer’s and other Neurodegenerative Disorders
por: Lyubchenko, Yuri L
Publicado: (2013)

The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders
por: Morato Torres, C. Alejandra, et al.
Publicado: (2020)

Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders 2013
por: Squitti, Rosanna, et al.
Publicado: (2013)

Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
por: , Sanjay, et al.
Publicado: (2021)

Emerging Promise of Therapeutic Approaches Targeting Mitochondria in Neurodegenerative Disorders
por: Rahman, Md. Mominur, et al.
Publicado: (2023)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
por: Jęśko, Henryk, et al.
Publicado: (2021)

Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate
por: Pizcueta, Pilar, et al.
Publicado: (2023)

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration
por: Jęśko, Henryk, et al.
Publicado: (2018)

Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies
por: Squitti, Rosanna, et al.
Publicado: (2011)

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
por: Gamache, Julia, et al.
Publicado: (2020)

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer’s Disease and Other Neurodegenerative Disorders
por: Carlson, George A., et al.
Publicado: (2021)

PPARα: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases
por: Lin, Yijun, et al.
Publicado: (2022)

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach
por: Bordoni, Matteo, et al.
Publicado: (2020)

Neurodegenerative movement disorders: An epigenetics perspective and promise for the future
por: Murthy, Megha, et al.
Publicado: (2021)

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases
por: Golde, Todd E, et al.
Publicado: (2009)

Promising Molecular Targets for Pharmacological Therapy of Neurodegenerative Pathologies
por: Neganova, M. E., et al.
Publicado: (2020)

Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride
por: Banasik, Marek, et al.
Publicado: (2011)

Abscisic acid, a promising therapeutic molecule to prevent Alzheimer’s and neurodegenerative diseases
por: Sánchez-Pérez, Ana María
Publicado: (2019)

Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases
por: Doustar, Jonah, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k1lk4icr5le541eu117nd3m9bv