Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation

Human γδ T cells are potent cytotoxic effector cells, produce a variety of cytokines, and can acquire regulatory activity. Induction of FOXP3, the key transcription factor of regulatory T cells (Treg), by TGF-β in human Vγ9 Vδ2 T cells has been previously reported. Vitamin C is an antioxidant and ac...

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Detalles Bibliográficos
Autores principales: Kouakanou, Léonce, Peters, Christian, Sun, Qiwei, Floess, Stefan, Bhat, Jaydeep, Huehn, Jochen, Kabelitz, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162875/
https://www.ncbi.nlm.nih.gov/pubmed/32300237
http://dx.doi.org/10.1038/s41598-020-63572-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162875/
https://www.ncbi.nlm.nih.gov/pubmed/32300237
http://dx.doi.org/10.1038/s41598-020-63572-w

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