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Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontaneously develop steatosis without obesity in aging. St...
Autores principales: | Régnier, Marion, Polizzi, Arnaud, Smati, Sarra, Lukowicz, Céline, Fougerat, Anne, Lippi, Yannick, Fouché, Edwin, Lasserre, Frédéric, Naylies, Claire, Bétoulières, Colette, Barquissau, Valentin, Mouisel, Etienne, Bertrand-Michel, Justine, Batut, Aurélie, Saati, Talal Al, Canlet, Cécile, Tremblay-Franco, Marie, Ellero-Simatos, Sandrine, Langin, Dominique, Postic, Catherine, Wahli, Walter, Loiseau, Nicolas, Guillou, Hervé, Montagner, Alexandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162950/ https://www.ncbi.nlm.nih.gov/pubmed/32300166 http://dx.doi.org/10.1038/s41598-020-63579-3 |
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