Cargando…
Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
BACKGROUND: Precision therapeutics continuously make advances in cancer therapy, and a field of growing interest is the combination of targeted radionuclide therapy (TRNT) with potential radiosensitizing agents. This study evaluated whether the effects of in vitro TRNT, using the (177)Lu-labeled ant...
Autores principales: | Mortensen, Anja C. L., Morin, Eric, Brown, Christopher J., Lane, David P., Nestor, Marika |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163001/ https://www.ncbi.nlm.nih.gov/pubmed/32300907 http://dx.doi.org/10.1186/s13550-020-0613-7 |
Ejemplares similares
-
The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
por: Mortensen, Anja Charlotte Lundgren, et al.
Publicado: (2019) -
Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2
por: Chee, Sharon Min Qi, et al.
Publicado: (2014) -
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
por: Yuen, Tsz Ying, et al.
Publicado: (2019) -
Functionalized Double Strain-Promoted Stapled Peptides
for Inhibiting the p53-MDM2 Interaction
por: Sharma, Krishna, et al.
Publicado: (2020) -
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays
por: Xiong Tan, Ban, et al.
Publicado: (2015)