Cargando…

The Pyrimidine Analog FNC Potently Inhibits the Replication of Multiple Enteroviruses

Human enteroviruses (EVs), including coxsackieviruses, the numbered enteroviruses, and echoviruses, cause a wide range of diseases, such as hand, foot, and mouth disease (HFMD), encephalitis, myocarditis, acute flaccid myelitis (AFM), pneumonia, and bronchiolitis. Therefore, broad-spectrum anti-EV d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Na, Yang, Jing, Zheng, Baisong, Zhang, Yan, Cao, Yiming, Huan, Chen, Wang, Shengqi, Chang, Junbiao, Zhang, Wenyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163137/ https://www.ncbi.nlm.nih.gov/pubmed/32075935 http://dx.doi.org/10.1128/JVI.00204-20

Ejemplares similares

Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters
por: Takamatsu, Yuki, et al.
Publicado: (2022)

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
por: Shen, Liang, et al.
Publicado: (2019)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

Immunization by Replication-Competent Controlled Herpesvirus Vectors
por: Bloom, David C., et al.
Publicado: (2018)

The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells
por: Matsuyama, Shutoku, et al.
Publicado: (2020)

Inhibition of Poxvirus Gene Expression and Genome Replication by Bisbenzimide Derivatives
por: Yakimovich, Artur, et al.
Publicado: (2017)

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication
por: Guedán, Anabel, et al.
Publicado: (2017)

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
por: Boyer, Paul L., et al.
Publicado: (2019)

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses
por: Carnell, George W., et al.
Publicado: (2021)

A Novel Attenuated Enterovirus A71 Mutant with VP1-V238A,K244R Exhibits Reduced Efficiency of Cell Entry/Exit and Augmented Binding Affinity to Sulfated Glycans
por: Meng, Tao, et al.
Publicado: (2021)

Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity
por: Zhu, Yuanmei, et al.
Publicado: (2020)

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses
por: Crosby, Catherine M., et al.
Publicado: (2017)

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern
por: Yuan, Mengqi, et al.
Publicado: (2022)

Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan-Independent Route of Entry
por: Murray, M. J., et al.
Publicado: (2020)

Assembly of Replication-Incompetent African Horse Sickness Virus Particles: Rational Design of Vaccines for All Serotypes
por: Lulla, Valeria, et al.
Publicado: (2016)

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen
por: Liu, Shufeng, et al.
Publicado: (2022)

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
por: Ribó-Molina, Pau, et al.
Publicado: (2023)

Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses
por: Beltran-Pavez, Carolina, et al.
Publicado: (2022)

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness
por: Mounce, Bryan C., et al.
Publicado: (2017)

Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase
por: Kim, Yu-Jin, et al.
Publicado: (2021)

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
por: Dahal, Subha, et al.
Publicado: (2023)

A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
por: Jones, Andrew T., et al.
Publicado: (2018)

A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV
por: Zhao, Guangyu, et al.
Publicado: (2018)

Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In Vivo
por: Ellis, Samantha, et al.
Publicado: (2018)

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C
por: Ulferts, Rachel, et al.
Publicado: (2016)

Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library
por: Wang, Peilin, et al.
Publicado: (2018)

Screening of Botanical Drugs against Lassa Virus Entry
por: Liu, Yang, et al.
Publicado: (2021)

Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
por: Zhang, Yuting, et al.
Publicado: (2022)

Mechanism through Which Retrocyclin Targets Flavivirus Multiplication
por: Jia, Xiaoying, et al.
Publicado: (2021)

Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection
por: Zhang, Yudi, et al.
Publicado: (2022)

Repurposing Nucleoside Analogs for Human Coronaviruses
por: Zandi, Keivan, et al.
Publicado: (2020)

A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice
por: Cao, Kangli, et al.
Publicado: (2022)

African Swine Fever Virus Bearing an I226R Gene Deletion Elicits Robust Immunity in Pigs to African Swine Fever
por: Zhang, Yanyan, et al.
Publicado: (2021)

Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease
por: Wang, Hualei, et al.
Publicado: (2019)

Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
por: van Haaren, M. M., et al.
Publicado: (2021)

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β
por: Wang, Chongyang, et al.
Publicado: (2023)

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening
por: Yang, Xuehua, et al.
Publicado: (2023)

Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle
por: Yang, Fang, et al.
Publicado: (2021)

A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity
por: Dong, Hu, et al.
Publicado: (2021)

Sequential Deletions of Interferon Inhibitors MGF110-9L and MGF505-7R Result in Sterile Immunity against the Eurasia Strain of Africa Swine Fever
por: Ding, Mingyang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5euiugv6befuunokqkc6if46o4