First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft

BACKGROUND: Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm(2) preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantati...

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Detalles Bibliográficos
Autores principales: Prat-Vidal, Cristina, Rodríguez-Gómez, Luciano, Aylagas, Miriam, Nieto-Nicolau, Nuria, Gastelurrutia, Paloma, Agustí, Elba, Gálvez-Montón, Carolina, Jorba, Ignasi, Teis, Albert, Monguió-Tortajada, Marta, Roura, Santiago, Vives, Joaquim, Torrents-Zapata, Silvia, Coca, María Isabel, Reales, Laura, Cámara-Rosell, María Luisa, Cediel, Germán, Coll, Ruth, Farré, Ramon, Navajas, Daniel, Vilarrodona, Anna, García-López, Joan, Muñoz-Guijosa, Christian, Querol, Sergi, Bayes-Genis, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163319/
https://www.ncbi.nlm.nih.gov/pubmed/32304998
http://dx.doi.org/10.1016/j.ebiom.2020.102729

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