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3D approaches to model the tumor microenvironment of pancreatic cancer

In tumor engineering, 3D approaches are used to model components of the tumor microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial unmet need and survival rates are lower compared to any other cancer. Bioengineering techniques are increasingly applied to unders...

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Autores principales: Tomás-Bort, Elena, Kieler, Markus, Sharma, Shreya, Candido, Juliana B, Loessner, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163433/
https://www.ncbi.nlm.nih.gov/pubmed/32308769
http://dx.doi.org/10.7150/thno.42441
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author Tomás-Bort, Elena
Kieler, Markus
Sharma, Shreya
Candido, Juliana B
Loessner, Daniela
author_facet Tomás-Bort, Elena
Kieler, Markus
Sharma, Shreya
Candido, Juliana B
Loessner, Daniela
author_sort Tomás-Bort, Elena
collection PubMed
description In tumor engineering, 3D approaches are used to model components of the tumor microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial unmet need and survival rates are lower compared to any other cancer. Bioengineering techniques are increasingly applied to understand the unique biology of pancreatic tumors and to design patient-specific models. Here we summarize how extracellular and cellular elements of the pancreatic tumor microenvironment and their interactions have been studied in 3D cell cultures. We review selected clinical trials, assess the benefits of therapies interfering with the tumor microenvironment and address their limitations and future perspectives.
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spelling pubmed-71634332020-04-17 3D approaches to model the tumor microenvironment of pancreatic cancer Tomás-Bort, Elena Kieler, Markus Sharma, Shreya Candido, Juliana B Loessner, Daniela Theranostics Review In tumor engineering, 3D approaches are used to model components of the tumor microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial unmet need and survival rates are lower compared to any other cancer. Bioengineering techniques are increasingly applied to understand the unique biology of pancreatic tumors and to design patient-specific models. Here we summarize how extracellular and cellular elements of the pancreatic tumor microenvironment and their interactions have been studied in 3D cell cultures. We review selected clinical trials, assess the benefits of therapies interfering with the tumor microenvironment and address their limitations and future perspectives. Ivyspring International Publisher 2020-04-06 /pmc/articles/PMC7163433/ /pubmed/32308769 http://dx.doi.org/10.7150/thno.42441 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Tomás-Bort, Elena
Kieler, Markus
Sharma, Shreya
Candido, Juliana B
Loessner, Daniela
3D approaches to model the tumor microenvironment of pancreatic cancer
title 3D approaches to model the tumor microenvironment of pancreatic cancer
title_full 3D approaches to model the tumor microenvironment of pancreatic cancer
title_fullStr 3D approaches to model the tumor microenvironment of pancreatic cancer
title_full_unstemmed 3D approaches to model the tumor microenvironment of pancreatic cancer
title_short 3D approaches to model the tumor microenvironment of pancreatic cancer
title_sort 3d approaches to model the tumor microenvironment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163433/
https://www.ncbi.nlm.nih.gov/pubmed/32308769
http://dx.doi.org/10.7150/thno.42441
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