Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation

Background and Purpose: RAS mutations limit the effectiveness of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in combination with chemotherapy for metastatic colorectal cancer (mCRC) patients. Therefore, new cell death forms have focused on identifying indirect targets to inhib...

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Detalles Bibliográficos
Autores principales: Chen, Peng, Li, Xuejie, Zhang, Ruonan, Liu, Shuiping, Xiang, Yu, Zhang, Mingming, Chen, Xiaying, Pan, Ting, Yan, Lili, Feng, Jiao, Duan, Ting, Wang, Da, Chen, Bi, Jin, Ting, Wang, Wengang, Chen, Liuxi, Huang, Xingxing, Zhang, Wenzheng, Sun, Yitian, Li, Guohua, Kong, Lingpan, Chen, Xiaohui, Li, Yongqiang, Yang, Zuyi, Zhang, Qin, Zhuo, Lvjia, Sui, Xinbing, Xie, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163451/
https://www.ncbi.nlm.nih.gov/pubmed/32308771
http://dx.doi.org/10.7150/thno.44705

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