Cargando…
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease
INTRODUCTION: Genome-wide association studies (GWAS) have successfully identified multiple independent genetic loci that harbour variants associated with Alzheimer’s disease, but the exact causal genes and biological pathways are largely unknown. METHODS: To prioritise likely causal genes associated...
Autores principales: | Gerring, Zachary F., Lupton, Michelle K., Edey, Daniel, Gamazon, Eric R., Derks, Eske M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164172/ https://www.ncbi.nlm.nih.gov/pubmed/32299494 http://dx.doi.org/10.1186/s13195-020-00611-8 |
Ejemplares similares
-
Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease
por: Gerring, Zachary F., et al.
Publicado: (2021) -
A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression
por: Gerring, Zachary F., et al.
Publicado: (2019) -
Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits
por: Gamazon, Eric R., et al.
Publicado: (2019) -
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder
por: Gaspar, Héléna A., et al.
Publicado: (2019) -
Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
por: Gamazon, Eric R., et al.
Publicado: (2018)