Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines

OBJECTIVE: Uveal melanoma is a rare intraocular malignancy. Half of the patients diagnosed will develop metastases within 10 to 30 years, most commonly in the liver. Although there has been a significant development in the treatment of melanoma, no effective treatment to prevent or treat metastases...

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Autores principales: Tilgase, Andra, Grīne, Lita, Blāķe, Ilze, Borodušķis, Mārtiņs, Rasa, Agnija, Alberts, Pēteris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164219/
https://www.ncbi.nlm.nih.gov/pubmed/32299493
http://dx.doi.org/10.1186/s13104-020-05068-4
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author Tilgase, Andra
Grīne, Lita
Blāķe, Ilze
Borodušķis, Mārtiņs
Rasa, Agnija
Alberts, Pēteris
author_facet Tilgase, Andra
Grīne, Lita
Blāķe, Ilze
Borodušķis, Mārtiņs
Rasa, Agnija
Alberts, Pēteris
author_sort Tilgase, Andra
collection PubMed
description OBJECTIVE: Uveal melanoma is a rare intraocular malignancy. Half of the patients diagnosed will develop metastases within 10 to 30 years, most commonly in the liver. Although there has been a significant development in the treatment of melanoma, no effective treatment to prevent or treat metastases of uveal melanoma is available. Oncolytic viruses are now being studied for various types of cancers and show promising results. Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines. The aim of this study was to test the possible cytolytic activity in human uveal melanoma cell lines. RESULTS: The results suggest cytolytic activity of oncolytic ECHO-7 virus strain Rigvir in MP41, 92-1 and Mel-202 cell lines.
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spelling pubmed-71642192020-04-22 Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines Tilgase, Andra Grīne, Lita Blāķe, Ilze Borodušķis, Mārtiņs Rasa, Agnija Alberts, Pēteris BMC Res Notes Research Note OBJECTIVE: Uveal melanoma is a rare intraocular malignancy. Half of the patients diagnosed will develop metastases within 10 to 30 years, most commonly in the liver. Although there has been a significant development in the treatment of melanoma, no effective treatment to prevent or treat metastases of uveal melanoma is available. Oncolytic viruses are now being studied for various types of cancers and show promising results. Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines. The aim of this study was to test the possible cytolytic activity in human uveal melanoma cell lines. RESULTS: The results suggest cytolytic activity of oncolytic ECHO-7 virus strain Rigvir in MP41, 92-1 and Mel-202 cell lines. BioMed Central 2020-04-16 /pmc/articles/PMC7164219/ /pubmed/32299493 http://dx.doi.org/10.1186/s13104-020-05068-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Tilgase, Andra
Grīne, Lita
Blāķe, Ilze
Borodušķis, Mārtiņs
Rasa, Agnija
Alberts, Pēteris
Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title_full Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title_fullStr Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title_full_unstemmed Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title_short Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines
title_sort effect of oncolytic echo-7 virus strain rigvir on uveal melanoma cell lines
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164219/
https://www.ncbi.nlm.nih.gov/pubmed/32299493
http://dx.doi.org/10.1186/s13104-020-05068-4
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