Exosomal miRNAs in tumor microenvironment

Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing activ...

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Detalles Bibliográficos
Autores principales: Tan, Shiming, Xia, Longzheng, Yi, Pin, Han, Yaqian, Tang, Lu, Pan, Qing, Tian, Yutong, Rao, Shan, Oyang, Linda, Liang, Jiaxin, Lin, Jinguan, Su, Min, Shi, Yingrui, Cao, Deliang, Zhou, Yujuan, Liao, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164281/
https://www.ncbi.nlm.nih.gov/pubmed/32299469
http://dx.doi.org/10.1186/s13046-020-01570-6
Descripción
Sumario:Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

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