Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

BACKGROUND: Isolated diaphragmatic metastasis is rarely associated with periosteal osteosarcoma. CASE PRESENTATION: A 24-year-old female patient was found to have periosteal osteosarcoma of the right humerus 11 years ago. Computed tomography showed a mass in her left chest in 2018, and thoracotomy w...

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Autores principales: Zhao, Luo, Qin, Yingzhi, Ma, Dongjie, Wang, Wenze, Li, Shanqing, Liu, Hongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164283/
https://www.ncbi.nlm.nih.gov/pubmed/32299473
http://dx.doi.org/10.1186/s13019-020-01103-4
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author Zhao, Luo
Qin, Yingzhi
Ma, Dongjie
Wang, Wenze
Li, Shanqing
Liu, Hongsheng
author_facet Zhao, Luo
Qin, Yingzhi
Ma, Dongjie
Wang, Wenze
Li, Shanqing
Liu, Hongsheng
author_sort Zhao, Luo
collection PubMed
description BACKGROUND: Isolated diaphragmatic metastasis is rarely associated with periosteal osteosarcoma. CASE PRESENTATION: A 24-year-old female patient was found to have periosteal osteosarcoma of the right humerus 11 years ago. Computed tomography showed a mass in her left chest in 2018, and thoracotomy was performed to remove the tumour. The tumour showed the same characteristics as the original periosteal osteosarcoma. Genetic analysis of the tumour sample showed a TP53 point mutation and CCNE1 gene copy number variants. CONCLUSIONS: We believe this is the first case report of haematogenous metastasis to the diaphragm of periosteal osteosarcoma, and an investigation of the genetic factors may help to unravel the underlying cause of periosteal osteosarcoma.
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spelling pubmed-71642832020-04-22 Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report Zhao, Luo Qin, Yingzhi Ma, Dongjie Wang, Wenze Li, Shanqing Liu, Hongsheng J Cardiothorac Surg Case Report BACKGROUND: Isolated diaphragmatic metastasis is rarely associated with periosteal osteosarcoma. CASE PRESENTATION: A 24-year-old female patient was found to have periosteal osteosarcoma of the right humerus 11 years ago. Computed tomography showed a mass in her left chest in 2018, and thoracotomy was performed to remove the tumour. The tumour showed the same characteristics as the original periosteal osteosarcoma. Genetic analysis of the tumour sample showed a TP53 point mutation and CCNE1 gene copy number variants. CONCLUSIONS: We believe this is the first case report of haematogenous metastasis to the diaphragm of periosteal osteosarcoma, and an investigation of the genetic factors may help to unravel the underlying cause of periosteal osteosarcoma. BioMed Central 2020-04-16 /pmc/articles/PMC7164283/ /pubmed/32299473 http://dx.doi.org/10.1186/s13019-020-01103-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zhao, Luo
Qin, Yingzhi
Ma, Dongjie
Wang, Wenze
Li, Shanqing
Liu, Hongsheng
Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title_full Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title_fullStr Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title_full_unstemmed Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title_short Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
title_sort isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164283/
https://www.ncbi.nlm.nih.gov/pubmed/32299473
http://dx.doi.org/10.1186/s13019-020-01103-4
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