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Myasthenia gravis and sugammadex: A case report and review of the literature

Anesthesia care during surgical procedures in patients with myasthenia gravis (MG) can be challenging, as these patients have increased sensitivity to neuromuscular blocking agents (NMBAs) and may be at high risk for postoperative weakness and respiratory failure. Even intermediate-acting NMBAs may...

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Autores principales: Dontukurthy, Sujana, Wisler, Carrie, Raman, Vidya, Tobias, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164480/
https://www.ncbi.nlm.nih.gov/pubmed/32317886
http://dx.doi.org/10.4103/sja.SJA_721_19
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author Dontukurthy, Sujana
Wisler, Carrie
Raman, Vidya
Tobias, Joseph D.
author_facet Dontukurthy, Sujana
Wisler, Carrie
Raman, Vidya
Tobias, Joseph D.
author_sort Dontukurthy, Sujana
collection PubMed
description Anesthesia care during surgical procedures in patients with myasthenia gravis (MG) can be challenging, as these patients have increased sensitivity to neuromuscular blocking agents (NMBAs) and may be at high risk for postoperative weakness and respiratory failure. Even intermediate-acting NMBAs may have a prolonged effect resulting in residual weakness after reversal with acetylcholinesterase inhibitors (neostigmine). Sugammadex (Bridion®, Merck and Co, Whithouse Stations, New Jersey) is a novel pharmacologic agent that reverses neuromuscular blockade by encapsulating rocuronium or vecuronium. We report the perioperative management of a 13-year-old adolescent girl with MG undergoing thymectomy. The use of sugammadex for reversal of neuromuscular blockade is discussed and the previous reports regarding its use in patients with MG are reviewed.
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spelling pubmed-71644802020-04-21 Myasthenia gravis and sugammadex: A case report and review of the literature Dontukurthy, Sujana Wisler, Carrie Raman, Vidya Tobias, Joseph D. Saudi J Anaesth Case Report Anesthesia care during surgical procedures in patients with myasthenia gravis (MG) can be challenging, as these patients have increased sensitivity to neuromuscular blocking agents (NMBAs) and may be at high risk for postoperative weakness and respiratory failure. Even intermediate-acting NMBAs may have a prolonged effect resulting in residual weakness after reversal with acetylcholinesterase inhibitors (neostigmine). Sugammadex (Bridion®, Merck and Co, Whithouse Stations, New Jersey) is a novel pharmacologic agent that reverses neuromuscular blockade by encapsulating rocuronium or vecuronium. We report the perioperative management of a 13-year-old adolescent girl with MG undergoing thymectomy. The use of sugammadex for reversal of neuromuscular blockade is discussed and the previous reports regarding its use in patients with MG are reviewed. Wolters Kluwer - Medknow 2020 2020-03-05 /pmc/articles/PMC7164480/ /pubmed/32317886 http://dx.doi.org/10.4103/sja.SJA_721_19 Text en Copyright: © 2020 Saudi Journal of Anesthesia http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Dontukurthy, Sujana
Wisler, Carrie
Raman, Vidya
Tobias, Joseph D.
Myasthenia gravis and sugammadex: A case report and review of the literature
title Myasthenia gravis and sugammadex: A case report and review of the literature
title_full Myasthenia gravis and sugammadex: A case report and review of the literature
title_fullStr Myasthenia gravis and sugammadex: A case report and review of the literature
title_full_unstemmed Myasthenia gravis and sugammadex: A case report and review of the literature
title_short Myasthenia gravis and sugammadex: A case report and review of the literature
title_sort myasthenia gravis and sugammadex: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164480/
https://www.ncbi.nlm.nih.gov/pubmed/32317886
http://dx.doi.org/10.4103/sja.SJA_721_19
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