Cargando…

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target among coronaviruses is the main protease (M(pro), also called 3CL(pro)) because of its essential role in processing the poly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Linlin, Lin, Daizong, Sun, Xinyuanyuan, Curth, Ute, Drosten, Christian, Sauerhering, Lucie, Becker, Stephan, Rox, Katharina, Hilgenfeld, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164518/ https://www.ncbi.nlm.nih.gov/pubmed/32198291 http://dx.doi.org/10.1126/science.abb3405

Ejemplares similares

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
por: Cooper, Mark S., et al.
Publicado: (2022)

From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease †
por: Göhl, Matthias, et al.
Publicado: (2022)

H172Y mutation perturbs the S1 pocket and nirmatrelvir binding of SARS-CoV-2 main protease through a nonnative hydrogen bond
por: de Oliveira, Vinicius Martins, et al.
Publicado: (2022)

An Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease
por: Clayton, Joseph, et al.
Publicado: (2023)

An insight into the interaction between α-ketoamide- based inhibitor and coronavirus main protease: A detailed in silico study
por: Banerjee, Snehasis
Publicado: (2021)

COVID-19: In silico identification of potent α-ketoamide inhibitors targeting the main protease of the SARS-CoV-2
por: Oubahmane, Mehdi, et al.
Publicado: (2021)

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
por: Lei, Jian, et al.
Publicado: (2014)

Identification of non-covalent SARS-CoV-2 main protease inhibitors by a virtual screen of commercially available drug-like compounds
por: Zhang, Linlin, et al.
Publicado: (2021)

Rapid synthesis of internal peptidyl α-ketoamides by on resin oxidation for the construction of rhomboid protease inhibitors
por: Van Kersavond, Tim, et al.
Publicado: (2021)

Inhibition of SARS-CoV-2 main protease 3CL(pro) by means of α-ketoamide and pyridone-containing pharmaceuticals using in silico molecular docking
por: Elzupir, Amin O.
Publicado: (2020)

Microwave irradiation: synthesis and characterization of α-ketoamide and bis (α-ketoamide) derivatives via the ring opening of N-acetylisatin
por: El-Faham, Ayman, et al.
Publicado: (2014)

Correction: Rapid synthesis of internal peptidyl α-ketoamides by on resin oxidation for the construction of rhomboid protease inhibitors
por: Van Kersavond, Tim, et al.
Publicado: (2021)

Identification of a Dual Inhibitor of Secreted Phospholipase A(2) (GIIA sPLA(2)) and SARS-CoV-2 Main Protease
por: Theodoropoulou, Maria A., et al.
Publicado: (2022)

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
por: Zhu, Lili, et al.
Publicado: (2011)

Interaction of the prototypical α-ketoamide inhibitor with the SARS-CoV-2 main protease active site in silico: Molecular dynamic simulations highlight the stability of the ligand-protein complex
por: Liang, Julia, et al.
Publicado: (2020)

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2–P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach
por: Achilonu, Ikechukwu, et al.
Publicado: (2020)

Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
por: Poláchová, Edita, et al.
Publicado: (2022)

Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
por: Wang, Lei, et al.
Publicado: (2015)

Rh(I)-Catalyzed Intermolecular Hydroacylation: Enantioselective Cross-Coupling of Aldehydes and Ketoamides
por: Kou, Kevin G. M., et al.
Publicado: (2014)

Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source
por: Xiao, Yuanyuan, et al.
Publicado: (2020)

Discovery of novel bicyclic[3.3.0]proline peptidyl α-ketoamides as potent 3CL-protease inhibitors for SARS-CoV-2
por: Chen, Xiaoxin, et al.
Publicado: (2023)

Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332
por: Li, Jian, et al.
Publicado: (2022)

Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
por: Li, Jian, et al.
Publicado: (2022)

Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
por: Hu, Xiaohui, et al.
Publicado: (2022)

A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities
por: Wang, Juan, et al.
Publicado: (2021)

Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides
por: Kim, Yunjeong, et al.
Publicado: (2016)

Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides
por: Roslan, Irwan Iskandar, et al.
Publicado: (2017)

Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications
por: Zhang, Zhiguo, et al.
Publicado: (2017)

Introduction of the α-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs
por: Meng, Tingting, et al.
Publicado: (2019)

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL(pro) and M(pro) proteases, and nsp14 guanine N7-methyltransferase
por: Zmudzinski, Mikolaj, et al.
Publicado: (2023)

Coronavirus main proteinase: target for antiviral drug therapy
por: Anand, Kanchan, et al.
Publicado: (2005)

Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin
por: Lei, Jian, et al.
Publicado: (2016)

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
por: Zhao, Yao, et al.
Publicado: (2021)

Improved synthesis of rupintrivir
por: Lin, DaiZong, et al.
Publicado: (2012)

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease
por: Mengist, Hylemariam Mihiretie, et al.
Publicado: (2021)

Structure–Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family
por: Zhou, Juan, et al.
Publicado: (2020)

Silver-Catalyzed Decarboxylative Acylation of Isocyanides Accesses to α-Ketoamides with Air as a Sole Oxidant
por: Xu, Jia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kc7rg2lj9ckt0pmep31khvrhk4