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Exposure to dim light at night prior to conception attenuates offspring innate immune responses

Functional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses a...

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Autores principales: Cissé, Yasmine M., Russart, Kathryn, Nelson, Randy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164648/
https://www.ncbi.nlm.nih.gov/pubmed/32302341
http://dx.doi.org/10.1371/journal.pone.0231140
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author Cissé, Yasmine M.
Russart, Kathryn
Nelson, Randy J.
author_facet Cissé, Yasmine M.
Russart, Kathryn
Nelson, Randy J.
author_sort Cissé, Yasmine M.
collection PubMed
description Functional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses are associated with disrupted endogenous gene transcriptional and endocrine cycles. However, few studies have addressed the multigenerational consequences of systemic circadian rhythm disruption. We hypothesized that parental exposure to dim LAN (dLAN) would alter innate immune and sickness responses to an endotoxin challenge in adult offspring gestated and reared in dark nights. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 8 weeks, then paired, mated, and thereafter housed under dark nights. Maternal exposure to dLAN prior to conception impaired febrile responses and increased splenic il-1 production in response to LPS in male offspring. Paternal pre-conception dLAN dampened offspring tnf-α expression in the hypothalamus, reduced serum bactericidal capacity, and dark phase locomotor activity. These changes occurred despite offspring being conceived, gestated, and reared under standard dark night conditions. Overall, these data suggest that dLAN has intergenerational effects on innate immunity and sickness responses.
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spelling pubmed-71646482020-04-22 Exposure to dim light at night prior to conception attenuates offspring innate immune responses Cissé, Yasmine M. Russart, Kathryn Nelson, Randy J. PLoS One Research Article Functional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses are associated with disrupted endogenous gene transcriptional and endocrine cycles. However, few studies have addressed the multigenerational consequences of systemic circadian rhythm disruption. We hypothesized that parental exposure to dim LAN (dLAN) would alter innate immune and sickness responses to an endotoxin challenge in adult offspring gestated and reared in dark nights. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 8 weeks, then paired, mated, and thereafter housed under dark nights. Maternal exposure to dLAN prior to conception impaired febrile responses and increased splenic il-1 production in response to LPS in male offspring. Paternal pre-conception dLAN dampened offspring tnf-α expression in the hypothalamus, reduced serum bactericidal capacity, and dark phase locomotor activity. These changes occurred despite offspring being conceived, gestated, and reared under standard dark night conditions. Overall, these data suggest that dLAN has intergenerational effects on innate immunity and sickness responses. Public Library of Science 2020-04-17 /pmc/articles/PMC7164648/ /pubmed/32302341 http://dx.doi.org/10.1371/journal.pone.0231140 Text en © 2020 Cissé et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cissé, Yasmine M.
Russart, Kathryn
Nelson, Randy J.
Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title_full Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title_fullStr Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title_full_unstemmed Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title_short Exposure to dim light at night prior to conception attenuates offspring innate immune responses
title_sort exposure to dim light at night prior to conception attenuates offspring innate immune responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164648/
https://www.ncbi.nlm.nih.gov/pubmed/32302341
http://dx.doi.org/10.1371/journal.pone.0231140
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