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Commensal epitopes drive differentiation of colonic T(regs)

The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously sensed by the immune system but typically do not elicit lymphocyte responses. CD4(+) T cells are critical to sustain uninterrupted tolerance to microbial antigens and to prevent intestinal inflammation. How...

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Detalles Bibliográficos
Autores principales: Kuczma, Michal P., Szurek, Edyta A., Cebula, Anna, Chassaing, Benoit, Jung, Yu-Jin, Kang, Sang-Moo, Fox, James G., Stecher, Bärbel, Ignatowicz, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164940/
https://www.ncbi.nlm.nih.gov/pubmed/32494613
http://dx.doi.org/10.1126/sciadv.aaz3186