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Use of local genetic ancestry to assess TOMM40-523′ and risk for Alzheimer disease

OBJECTIVE: Here, we re-examine TOMM40-523′ as a race/ethnicity-specific risk modifier for late-onset Alzheimer disease (LOAD) with adjustment for local genomic ancestry (LGA) in Apolipoprotein E (APOE) ε4 haplotypes. METHODS: The TOMM40-523′ size was determined by fragment analysis and whole genome...

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Detalles Bibliográficos
Autores principales:	Bussies, Parker L., Rajabli, Farid, Griswold, Anthony, Dorfsman, Daniel A., Whitehead, Patrice, Adams, Larry D., Mena, Pedro R., Cuccaro, Michael, Haines, Jonathan L., Byrd, Goldie S., Beecham, Gary W., Pericak-Vance, Margaret A., Young, Juan I., Vance, Jeffery M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164968/ https://www.ncbi.nlm.nih.gov/pubmed/32337333 http://dx.doi.org/10.1212/NXG.0000000000000404

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