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Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells

To address unmet clinical need for uveal melanomas, we assessed the effects of BH3-mimetic molecules, the ABT family, known to exert pro-apoptotic activities in cancer cells. Our results uncovered that ABT-263 (Navitoclax), a potent and orally bioavailable BCL-2 family inhibitor, induced antiprolife...

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Detalles Bibliográficos
Autores principales:	Bellini, Lara, Strub, Thomas, Habel, Nadia, Pandiani, Charlotte, Marchetti, Sandrine, Martel, Arnaud, Baillif, Stéphanie, Bailly-Maitre, Béatrice, Gual, Philippe, Ballotti, Robert, Bertolotto, Corine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165182/ https://www.ncbi.nlm.nih.gov/pubmed/32337074 http://dx.doi.org/10.1038/s41420-020-0259-2

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