Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy

Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe(3)O(4)-decorated hollow graphene microspheres (rGO@Fe(3)O(4)) by a facile spray drying and coprecipitation method for the magnetically tar...

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Autores principales: Liang, Chunyong, Song, Jiying, Zhang, Yongguang, Guo, Yaping, Deng, Meigui, Gao, Wei, Zhang, Jimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165235/
https://www.ncbi.nlm.nih.gov/pubmed/32303922
http://dx.doi.org/10.1186/s11671-020-03320-1
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author Liang, Chunyong
Song, Jiying
Zhang, Yongguang
Guo, Yaping
Deng, Meigui
Gao, Wei
Zhang, Jimin
author_facet Liang, Chunyong
Song, Jiying
Zhang, Yongguang
Guo, Yaping
Deng, Meigui
Gao, Wei
Zhang, Jimin
author_sort Liang, Chunyong
collection PubMed
description Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe(3)O(4)-decorated hollow graphene microspheres (rGO@Fe(3)O(4)) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (~ 120.7 m(2) g(−1)) and large pore volume (~ 1.012 cm(3) g(−1)), demonstrating distinct advantages for a high loading capacity of DOX (~ 18.43%). NIR triggered photothermal effect of the rGO@Fe(3)O(4) microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe(3)O(4) on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe(3)O(4)/DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe(3)O(4)/DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.
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spelling pubmed-71652352020-04-24 Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy Liang, Chunyong Song, Jiying Zhang, Yongguang Guo, Yaping Deng, Meigui Gao, Wei Zhang, Jimin Nanoscale Res Lett Nano Express Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe(3)O(4)-decorated hollow graphene microspheres (rGO@Fe(3)O(4)) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (~ 120.7 m(2) g(−1)) and large pore volume (~ 1.012 cm(3) g(−1)), demonstrating distinct advantages for a high loading capacity of DOX (~ 18.43%). NIR triggered photothermal effect of the rGO@Fe(3)O(4) microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe(3)O(4) on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe(3)O(4)/DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe(3)O(4)/DOX microcapsules have great potential in combined chemo-photothermal cancer treatment. Springer US 2020-04-17 /pmc/articles/PMC7165235/ /pubmed/32303922 http://dx.doi.org/10.1186/s11671-020-03320-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Nano Express
Liang, Chunyong
Song, Jiying
Zhang, Yongguang
Guo, Yaping
Deng, Meigui
Gao, Wei
Zhang, Jimin
Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title_full Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title_fullStr Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title_full_unstemmed Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title_short Facile Approach to Prepare rGO@Fe(3)O(4) Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
title_sort facile approach to prepare rgo@fe(3)o(4) microspheres for the magnetically targeted and nir-responsive chemo-photothermal combination therapy
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165235/
https://www.ncbi.nlm.nih.gov/pubmed/32303922
http://dx.doi.org/10.1186/s11671-020-03320-1
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